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Infectious Diseases

Contributed by:

Mary Cassatt
University of Medicine and Dentistry of New Jersey
Notes by: Ashley Quinn, Donna Lawson, and Mary Cassatt

Disclaimer: These notes were copied and pasted from files sent to me by Mary.  They have not been reviewed for errors. You are responsible for checking out the information to verify the accuracy. This site, Amy Nieves, Ashley Quinn, Donna Lawson, and Mary Cassatt are not responsible for typographical errors.

Chapter 4

I. Introduction

Microorganisms are divided into those who cause disease: Pathogenic

Those that do not: Nonpathogenic ( sometimes they do ) = opportunistic infection

Can be caused by immunosupression diseases

To cause disease the organism must gain access to the body, accommodate to growth in the human environment and avoid multiple host defenses.

BACTERIAL INFECTIONS

IMPETIGO

Not an oral Lesion, Skin infection

Face or extremities

YOUNG CHILDREN

Bacteria : Streptococcus pyogenes and Staphylcoccus aureus

Start off as Vesicles that rupture, then they crust,

Usually occur when they is already skin trauma: dermatitis

MAY RESEMBLE : Herpes Simplex Infection

Clinical Presentation is important unless cultures were taken bacteria can be identified,

Treatment: topical and systemic Antibiotics

Tonsilitis and Pharyngitis

Many different Bacteria casues this: streptococci, adenoviruses, influenza viruses and Epstien barr virus

Appearance - white patches on tonsils

Streptococcal tonsillitis and pharyngitis is a common bacteria infection : spread by contact with nasal or oral secretions

Antibiotics are used to treat Streptococcal infection

Scarlet fever : USUALLY IN CHILDREN

Break out in rash, strawberry tongue

Throat culture helpful

Rheumatic fever :  effects the heart , joints and nervous system

People recovering or who have this usually require : premed

TUBERCULOSIS ( bacteria)

“CHRONIC INFECTIION”

MYCOBACTERIUM TUBERCULOSIS

Primary infection of the -  LUNG

Fever chills fatigue malaise weight loss cough

Disease is WALLED OFF in the ling

Hard to treat

Chronic Granulomatous inflammatory lesions

Areas of necrosis surrounded by macrophages, multinucleated giant cells and lymphocytes

Treatment: multiple antibiotic regimens

Tongue and palate most common sites ( oral lesions not common)

Painful non healing slowly enlarging ulcers,

Reactivate: immuno depression

Identifeid:  Biopsy and microscopic examination of the tissue

PPD test - Type IV hypersensitivity reaction

Cell mediated immune response will activate if positive reaction

Chest radiograph must be done if result is positive

Meds Used:  isoniazid ( INH) and Rifampin,

Treatment lasts months to 2 years, Counsel patient on ongoing treatment

ACTINOMYCOSIS

Normal flora found in mouth, plaque , sulcus, perio pocket

Bacteria : Actinomyces isrealii

Most common from : abscesses, tend to drain by the Sinus tracts

Pus tiny BRIGHT YELLOW GRAINS-  don’t see in any other disease

Sulfur Granules  - due to their color

Microscopic exam

The infection is preceded by : Tooth extraction or abrasion of the mucosa

Identifying the colonies for diagnosis

Treated with:  long term high doses of antibiotics

Smells bad,

SYPHILIS                                page 164

Bacteria :  Spirochete Treponema pallidum

Direct contact

You need some kind of break in the skin to invade through

Can die when exposed to the air

PRIMARY

                                                                                                                                          2)  CHANCRE forms at the site of anoculation

1) Spirochete enters body,

accompanied by LYMPHADNAPATHY

this heals by itself, then it enters latent period

SECONDARY STAGE = MUCOUS PATCH

6 weeks later

eruptions in the skin and mucous membranes

Multiple , painless, grayish white plaques covering ulcerative mucosa

Most infectious stage

Tertiary Lesions

Years later

Involves cardiovascular systems and CNS

GUMMA : noninfectious

Hole in palate : not treat able

Firm mass,  then turns to ulcer

Tongue and palate: most common

Destructive lesion: perforation of palatal bone may occur

CoNGENITAL SYPHILIS

Infected MOTHER TO FETUS

Can  casue serious facial and dental abnormalities

DIAGNOSIS : microscopic technique

TWO BLOOD TEST ARE ASLO NEEDED (VDRL) and Fluorescent treponemal antibody absorption ( FTA-ABS)

Generally treated by PENICILLIAN

DETECTED BY TITER

NECROTIZING ULCERATIVE GINGIVITIS ( NUG)

Page 166-167

Painful erythemous gingivitis with necrosis of the interdental papilla

BASTERIA: fusiform bacillus and spirochete ( borelia vincentii) decreased resistance to infection

FOUL ODOR, metallic taste

Cratering of interdental area

Psuedomembrane over tiisues, sloughs off

Clinical features determine anug from acute marginal gingivitis and gingival componet of acute primary herpes simplex

Chlorhexadine rinses : treatment

Host response is needed

PERICORONITIS

Page 78-79

Inflammation  of the mucousa around the crown of a partially erupted tooth, or impacted

Most common mand. 3rd molars

Result of am infection from bacteria part of normal flora

Proliferate in tissue b/t soft tissue and crown

Compromised host defenses are associated with this

Trauma from opposing molar usuallt the casue and removal of this trauma is the treatment

Food impaction also may be a cause

DIAGNOSIS :  clinical presentaion, swollen, erythemous and painful

TREATMENT:  Mechanical debribment, irrigation of pocket and systemic antibiotics,  Extraction of impacted molar to prevent reoccurance

ACUTE OSTEOMYELITIS

Acute inflammation of bone and bone marrow

Jaws: most common

Result of extension of periapical abscess

It may follow Fracture of bone or surgery  and may also result from bacteremia

Diagnosis: culture results, or treatment to antibiotic sensitivity testing

Microscopic you will see: non viable bone, necrotic debris, acute inflammation and bacterial colonies in marrow spaces

Disease needs to be present for more then 1 week to see change in radiographs

Treatment:  drainage of the area, and use of proper antibiotics

CHRONIC OSTEOMYELITIS

Hard to treat

Body walls off  area

Sickle cell disease, pagets disease, bone irradation,

Involved bone is  PAINFUL, SWOLLEN

Radiographically:  diffuse and irregular radiolucency it will eventually become radioopaque

Radio Opaque = chronic sclerosing osteomyelitis

Diagnosis:  biopsy results and histological exam

Treatment: debribment and administration of systemic antibiotics

Some patients may need hyperbaric oxygen to successfully treat this

FUNGAL INFECTIONS

CANDIDIASIS

AKA : Moniliasis and THRUSH

Overgrowth of a yeast like fungus : Candida Albicans

MOST COMMON ORAL INFECTION

Normal flora : this particularly in those who wear denture

Can be casued by:

            Antibiotic therapy

            Cancer chemotherapy

            Corticosteriod therapy

            DENTURES

            DIABETES MELLITUS

            Hiv INFECTION

            Hypoparathroidism

            Infancy

            Multiple myeloma

            Primary T-Lymphocytes

            Xerostomia

Most common associated with immunodeficiency

Easily identified by a white plaque that wipes off

Many types

Pseudomembranous

White curdlike material: mucosa surface

Underlying mucosa is erythemous

Burning sensation is felt

Metallic taste also may be present

ERYTHEMATOUS CANDIDIASIS


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