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Blood Disorders

Contributed by:

Andrea and Cristal
SDH  PRCC, MS.

 

  1. What is the Connective tissue made up of cells and cell parts?

Blood.

  1. What is the liquid matrix of blood?

Plasma.

  1. All of the following are purposes of blood EXCEPT?
    1. Transports O2 to tissues.
    2. Carries carbon dioxide away from tissues.
    3. Maintains body weight.
    4. Maintains body temp.
    5. Maintain body fluid balance.
    6. Gives protection from foreign substances.
  1. What are the formed elements and state if they have nuclei or not?

 Erythrocytes (RBC) no nuclei,

 Leukocytes (WBC) have nucleus,

Thrombocytes (platelets) no nuclei.

  1. What are the components of normal blood?

 55% plasma fluid,

45% formed elements.

  1. What gives RBC their pigment?

Hemes, which is a red pigment.

  1. What protein chain binds to oxygen to make it red?

 Globin.

  1. What does WBC respond to?

Injury or invasion of microorganisms.

  1. What type of function does WBC have?

 Phagocytic.

  1. WBC contain no:

Hemoglobin.

  1. What are the 2 groups of WBC and their characteristics?

Agranulocytes: do no have granules in their cytoplasm.

Granulocytes: have granules in their cytoplasm.

  1. List the types of agranulocytes:

Lymphocyte, monocyte.

  1. Largest WBC and has a phagocytic function: Monocyte.
  1. What WBC produces antibodies and is able to recognize foreign invaders and trigger a response to them?

Lymphocyte.

  1. What are the 2 classes of lymphocytes?

T lymph & B lymph.

  1. T lymph is formed in the thymus and its function is to:

 Destroy foreign cells or aid other cells of the immune system.

  1. Where is B lymph formed and what does it produce?

 Formed in bone marrow and produces antibodies.

  1. There is 5 classes of B lymph, match the class of B lymph with its function:

 

IgG     D

A. Activates the B-cell. Immune system regulation.

IgA      B

B. Protects mucosal sites. Found in tears, saliva, breast milk

IgM    E

C. Attack parasites & may harm humans by causing allergies.

IgE      C

D. Crosses the placenta.

IgD       A

E.1st antibody produced in an immune response.

 

 

  1. There are 3 types of granulocytes, match them with their function & characteristics:

 

Neutrophils  B

A. Very few in number. Increase during an allergic reaction or even a parasitic infection.

Eosinophils  A

B. Most numerous of all WBC. 1st line of defense of the body. Phagocytic function. When they are dead they are called pus.

Basophils   C

C. Increase during inflammation, secrete heparin.

 

  1. What is heparin?

Blood thinner that helps prevent clotting of blood as it flows thru vessels.

  1. These are ¼ the size of RBC, and help in the clotting of blood and close capillaries at the time of injury. They also help dissolve clots after healing:

 Platelets.

  1. What is prothrombin? Protein present in normal blood, required for blood clotting.
  1. What stimulates the liver cells to increase prothrombin production?

 Vitamin K.

  1. What is the prothrombin time test for?

To see how fast the blood will clot, usually done before surgery.

  1. Reduction of the number of RBC to a level below what is normal:

Anemia.

  1. What are the causes of anemia?

Diminished production of RBC: nutritional deficiency/ bone marrow failure. Blood loss: internal lesion, trauma, disease.

  1. List the general characteristics of anemia:

Pale skin, weakness, headache, dimness of vision, brittle nails, feeling faint.

  1. Iron deficiency anemia occurs in young females, what are the causes?

Malnutrition, chronic blood loss so the body has an increased demand for iron.

  1. The oral signs of iron deficiency anemia are:

Real pale mucosa or gingival, inflammation of the tongue.

  1. How is iron deficiency anemia treated?

Oral iron tablets.

  1. What would liquid iron do to the teeth?

Discolor the teeth.

  1. What type of anemia has abnormally large RBC?

Megoblastic anemia.

  1. Folic acid anemia is a type of megoblastic anemia how is it treated?

 Eat green leafy vegetables.

  1. Pernicious anemia is a type of megoblastic anemia caused by a Vit. B deficiency, what is the best source for Vit B?

Liver.

  1. Has a defective shape of hemoglobin molecule and because of abnormal shape it stops up small blood vessels, which cause a crisis because no O2 is getting to the tissue. Occurs mostly in blacks and is hereditary. 

Sickle cell anemia.

  1. Oral signs and symptoms of sickle cell anemia: pale gingival, increase bone loss & pocket bleeding & infections.
  1. Polycythemia:

There is an increase number and concentration of RBC. Blood is too thick to flow properly, so it stops up little small vessels.

  1. What would be observed orally in a patient with polycythemia?

Enlarged gingival that bleed with slightest touch. Tongue, gingival, mucosa deep purplish red.

  1. What is a malignancy of blood forming cells in bone marrow, abnormal amount of WBC? Leukemia.
  1. List the signs or symptoms of leukemia:

Anemia, weight loss, headache, nausea, fatigue, fever.

  1. What are the oral signs/symptoms of leukemia?

Red/ blunted papilla that can be soft & spongy, can be enlarged, spontaneous bleeding, shedding of tongue, ulcerations on tongue.

  1. What steps should be followed when treating a patient with leukemia?

Premed because they are immuno suppressed. Rinse with anti microbial rinse. Encourage optimal OH.

  1. A genetic disorder where clotting is abnormal or absent, and occurs mostly in males? Hemophilia.
  1. Proposed treatment when treating a patient with hemophilia?

Premed, and perform tissue conditioning.

  1. What is tissue conditioning?

Cleaning the mouth in quads to allow for healing.

 

Disclaimer: These notes were copied and pasted from files sent to me by Andrea.  They have not been reviewed for errors. You are responsible for checking out the information to verify the accuracy. This site, Amy Nieves and Andrea are not responsible for typographical errors.